Voriconazole-d3
- Product Name
- Voriconazole-d3
- CAS No.
- 188416-29-7
- Chemical Name
- Voriconazole-d3
- Synonyms
- 3R)-2-(2;VORICONAZOLE-D3;Voriconazole PI-6;(2R,3R)-Voriconazole;Voriconazole Intermediate II;4-triazol-1-yl)-2-butanol (RaceMic Voriconazole);4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1;(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;(2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;(2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
- CBNumber
- CB92610550
- Molecular Formula
- C16H14F3N5O
- Formula Weight
- 349.31
- MOL File
- 188416-29-7.mol
Voriconazole-d3 Property
- Boiling point:
- 508.6±60.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- pka
- 11.54±0.29(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17803
- Product name
- Voriconazole-d3
- Purity
- ≥99% deuterated forms (d<sub>1</sub>-d<sub>3</sub>)
- Packaging
- 500 μg
- Price
- $175
- Updated
- 2023/06/20
- Product number
- 17803
- Product name
- Voriconazole-d3
- Purity
- ≥99% deuterated forms (d<sub>1</sub>-d<sub>3</sub>)
- Packaging
- 1 mg
- Price
- $306
- Updated
- 2023/06/20
- Product number
- V759995
- Product name
- (±)-Voriconazole
- Packaging
- 500mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- HCH0344808
- Product name
- (2R,3S,2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUORO-4-PYRIMIDINYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.38
- Updated
- 2021/12/16
- Product number
- 100266
- Product name
- (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $742
- Updated
- 2021/12/16
Voriconazole-d3 Chemical Properties,Usage,Production
Description
Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.
Uses
Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.
Application
Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.
References
1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946
Voriconazole-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
Voriconazole-d3 Suppliers
View Lastest Price from Voriconazole-d3 manufacturers
- Product
- (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) 188416-29-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24